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|Title: ||Retrospective study on HIV/AIDS associated haematological disorders found in bone marrow at Dr George Mukhari Hospital (DGMH), Pretoria|
|Authors: ||De Carvalho, Mariquinha Jose Manuel Moniz|
|Advisors: ||Culligan, G. A.|
|Keywords: ||Bone marrow|
|Issue Date: ||2010|
|Publisher: ||University of Limpopo (Medunsa Campus)|
|Abstract: ||Background. Infection with human immunodeficiency virus (HIV) is associated with a
range of haematological abnormalities including: ineffective haematopoiesis, infiltrative
disease of the bone marrow, nutritional deficiency and peripheral destruction of blood cells
secondary to splenomegaly and immune deregulation.
Aim. To review and describe bone marrow abnormalities and associated peripheral
haematological abnormalities, in HIV/AIDS patients.
Methodology. This is a retrospective study. Data was extracted from DISA, the National
Laboratory Health Service Laboratory Information System database at the DGMH Tertiary
Laboratory from 2003 to 2007. Medical and laboratory records of 80 HIV positive patients
who underwent bone marrow examination for investigation of fever and/or cytopenia were
reviewed. All statistical analyses were performed on SAS® Release 9.1.3.
Results. Twenty-five patients out of a total of 80 (31.25%), had pancytopaenia. Of the 25,
eight (32%) were males and 17 (68%) were females. In this study, pancytopaenia was
described as a haemoglobin concentration, granulocyte count and platelet count below
normal ranges for age and gender. Among male patients in this study, five (17%) patients
had TB out of 30. Among female patients, five (10%) out of 50 patients had TB. The
majority of patients with malignancies were males six out of nine (67%). Three of the five
patients with non-Hodgkin’s lymphoma (NHL) and all of the patients with multiple
myeloma (MM) were males.
Conclusions. Haematological abnormalities were present in all patients. Bone marrow
involvement by TB was found in 12.5% in the study population. Malignancies were more
frequent in males; three patients with NHL, two with MM and one with Kaposi sarcoma
(KS). The difference in distribution was not statistically significant (p=0.391002).
Recommendations. It is recommended that health education and health promotion focus
on the control of biological carcinogenic agents such as EBV, HPV and HHV-8 by
routinely testing for these agents and by promotion of positive reproductive behaviour
among people living with HIV/AIDS. The use of non-invasive tests will be helpful in our
setting where there is high TB prevalence.|
|Description: ||Thesis (M Med (Haematology))--University of Limpopo, 2010.|
|Appears in Collections:||Theses and Dissertations (Haematology)|
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